HWS
Psychological Science + Mathematics
Joint Colloquium
Differential profiles of structural brain network changes resulting
from traumatic brain injury
ABSTRACT: Traumatic brain injury (TBI)
damages white matter tracts and changes brain connectivity, but how specific
changes relate to differences in clinical/behavioral outcomes is not
known. Here, I’ll present recent work classifying different patterns of
change in brain network structure after injury in a rat model of TBI. We
find that local changes in motif coherence can be used to define subgroups
within injured rats that display different patterns of injury induced
change. Further, computational modeling of brain dynamics suggests that
these different underlying brain networks could be related to the observed
heterogeneity in clinical outcomes such as the propensity to develop epilepsy.